Protease

Enhance Digestion with Natural Pancreatic Proteins from Neova Technologies Inc.

With over twenty-five years of experience, Neova Technologies Inc. has established itself as a reliable source of high-quality pancreatic enzymes. Their enzyme preparations mimic natural digestive processes and offer tailored solutions to meet specific industry needs. Whether you are in food processing, pharmaceuticals, or any related field, Neova Technologies Inc. has the expertise and products to support your requirements. Enhance your production capabilities with the power of natural pancreatic proteins.

Natural pancreatic proteins play a vital role in food digestion. Neova Technologies Inc., a leading player in the global market for porcine-derived enzymes, has been active in the pancreatic enzyme market for over twenty-five years. Their comprehensive product range includes trypsin/chymotrypsin preparations and phospholipase A2 (PA2), catering to various sectors such as food, technical applications, nutraceuticals, and pharmaceuticals.

Key Enzymes: Trypsin and Chymotrypsin

Trypsin and Chymotrypsin are essential serine proteases with specific cleaving characteristics vital for protein digestion.

Trypsin:

• Function: Trypsin is an endopeptidase from the serine protease family. It hydrolyzes peptide bonds at the carboxyl end of essential amino acids like arginine or lysine. Additionally, trypsin can hydrolyze amide and ester bonds formed by the carboxyl groups of these amino acids.
• Extraction and Preparation: Trypsin is typically extracted from the pancreas of mammals such as cattle and pigs. It is purified, crystallized, and made into a freeze-dried product. Bovine trypsin has 223 amino acids and a molecular weight of 23,800 Daltons. Its active site contains a crucial serine residue.
• Properties: Trypsin is soluble in water but insoluble in organic solvents like ethanol, glycerol, and chloroform. It has an isoelectric point (pI) of 10.1, an optimal pH range of 7.8 to 8.5, and becomes irreversibly inactivated at pH values greater than 9.0. Calcium ions enhance and stabilize trypsin activity.

Trypsin is widely used across various industries, including food processing, pharmaceuticals, biochemical testing, and tanning. In the pharmaceutical sector, trypsin hydrolyzes natural and denatured proteins, fibrin, and mucin into polypeptides or amino acids, aiding in desensitization. Trypsin-based biopharmaceuticals treat respiratory conditions, dissolve mucus and purulent secretions, and manage poisonous snake bites. Due to non-specific aprotinin in serum, trypsin does not digest normal tissues but effectively decomposes viscous secretions, facilitating better penetration of antibiotics and chemotherapy drugs into affected areas.

Trypsin is primarily used to hydrolyze high-value animal and vegetable proteins in the food industry. For instance, in milk processing, trypsin hydrolyzes allergens like casein, α-lactalbumin, and β-lactoglobulin, resulting in hypoallergenic formula milk powder. In the tanning industry, trypsin is used to soften leather and extract collagen, which boasts excellent biocompatibility and biodegradability.

Chymotrypsin:

• Function: Chymotrypsin hydrolyzes peptide bonds involving phenylalanine (Phe), tyrosine (Tyr), and tryptophan (Trp).

Applications of Pancreatic Enzymes:

Neova Technologies Inc. offers enzyme preparations tailored to meet diverse functional requirements determined in consultation with customers. These enzymes are used in various applications, including:

Food Processing:

• Hydrolyzing animal and vegetable proteins
• Extracting seasonings and flavorings from proteins
• Manufacturing protein hydrolysates
• Producing hypoallergenic food

Dairy Supplements and Infant Formula:

• Controlling aroma formation in cheese and milk products
• Enhancing the texture of fish products
• Tenderizing meat
• Cold stabilization of beer

Biotechnological and Pharmaceutical Applications:

• Lab and cell culture media
• Vaccine development
• Collagen extraction

Protease products: